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Cryoglobulinemia causes Hep C Myeloma, Waldenstrom’s macroglobulinemia, SLE, Rheumatoid arthritis, Sjogren’s syndrome, Symptoms, Immunoglobulins precipitate when cooled under skin, ulcers, rashes, gangrene, Raynaud’s phenomenon. Treatment. Plasma exchange, Chemotherapy, Treat the cause.