Mebendazole and albendazole are benzimidazole carbamates that bind with high affinity to parasite-free B-tubulin to inhibit its polymerization and microtubule assembly. These agents also irreversibly inhibit glucose uptake by nematodes; the resulting glycogen depletion and decreased ATP production immobilize the intestinal parasite, which is then cleared from the GI tract.
Indications:
Mebendazole is the drug of choice for the treatment of Trichuris trichuria (whipworm), Enterobius vermicularis (horse pinworm, pinworm), Ascaris lumbricoides (roundworm), as well as hookworm Ancylostoma duodenale and Necator americanus. For all these helminth mebendazole has success rates of at least 90 to 95%. It is also recommended for the treatment of Echinococcus granulosus and E. multilocularis infections
Mebendazole is available in Pakistan in various brand names. Each brand name along with manufacturing pharmaceutical industry is given below.
Dose and treatment Course
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed, or crushed and mixed with food.
If the patient is not cured three weeks after treatment, a second course of treatment is advised. No special procedures, such as fasting or purging, are required.
ALMEB | ALSON PHARMACEUTICALS | ||
BELMENTIC | PARAMOUNT PHARMACEUTICALS | ||
BELMENTIC | PARAMOUNT PHARMACEUTICAL | ||
BELMENTIC | PARAMOUNT PHARMACEUTICALS | ||
BENDAMOX | UNEXO LABS (PVT) LTD | ||
ERIZOLE | EFROZE CHEMICAL INDUSTRIES (PVT) LTD. | ||
GEOZOLE | GEOFMAN PHARMACEUTICALS | ||
GEOZOLE | GEOFMAN PHARMACEUTICALS | ||
G-WORM | OLIVE LABORATORIES | ||
HELMOX | LAHORE CHEMICAL & PHARMACEUTICAL WORKS (PVT) LTD | ||
MEBEN | SPENCER PHARMA | ||
MEBENDAZOLE | BENSON PHARMACEUTICALS. | ||
MEBENDAZOLE | BENSON PHARMACEUTICALS. | ||
MEBEROWN | CROWN PHARMACEUTICALS | ’ | |
MEBNAGEN | GENERA PHARMACEUTICALS | ||
MEBNAGEN | GENERA PHARMACEUTICALS | ||
MENAREX | REX PHARMACEUTICALS PAKISTAN | ||
MENDAZOLE | VALOR PHARMACEUTICALS | ||
MEZONIL | DR. RAZA PHARMA (PRIVATE) LIMITED | ||
NEMAZOLE | GLAXOSMITHKLINE | ||
PANAMOX | LIFE LINE PHARMACEUTICALS (PVT.) LTD. | ||
PANAMOX | LIFE LINE PHARMACEUTICALS (PVT.) LTD. | ||
PAREX | INNVOTEK PHARMACEUTICALS | ||
PROVERM | PHARMEDIC (PVT) LTD. | ||
SPHINX | LIBRA PHARMACEUTICALS (PVT) LTD | ||
TAGAMEB | TAGMA PHARMA (PVT) LTD. | ||
VERMIN | ADAMJEE PHARMACEUTICALS (PVT) LTD. | ||
VERMOX | JANSSEN-CILAG | ||
WARTH | SAYDON PHARMACEUTICAL INDUSTRIES (PVT) LTD. | ||
WORCID | RAAZEE THERAPUTICS (PVT) LTD. | ||
WORMAZOLE | SIZA INTERNATIONAL (PVT) LTD. | ||
WORMDOX | MEDICEENA PHARMA (PVT) LTD. | ||
WORMDOX | MEDICEENA PHARMA (PVT) LTD. | ||
WORMIZOLE | EPLA LABORATORIES (PVT) LTD. | ||
ZENZOL | JAWA PHARMACEUTICALS(PVT) LTD. | ||
ZEWORM | WILSHIRE LABORATORIES (PVT) LTD. |
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed, or crushed and mixed with food.
Pinworm (enterobiasis) | Whipworm (trichuriasis) | Common Roundworm (ascariasis) | Hookworm | |
Dose | 1 tablet, once | 1 tablet morning and evening for 3 consecutive days. | 1 tablet morning and evening for 3 consecutive days. | 1 tablet morning and evening for 3 consecutive days. |