Skip to main content

Tricyclic Antidepressants - mechanism - indications - side/adverse effects- anti depressant drugs



Tricyclic Antidepressants:

Tricyclic antidepressants inhibit the retake of both serotonin and nor epinephrine. TCAs also block alpha adrenergic receptors, serotonergic, histaminic, muscarinic receptors. And blockage of these receptors is the cause of a big profile of side effects.

TCAs include the following drugs:

1)    Tertiary amines:
Ø     Imipramine
Ø     Amitriptyline
Ø     Clomipramine
Ø     Doxepin
Ø     Trimipramine

2)    Secondary amines:
Ø     Desipramine
Ø     Nortriptyline

3)    Tetra cyclic antidepressants:
Ø     Maprotiline
Ø     Amoxapine



Indications:

ü     Moderate to Severe Depression
ü     Panic disorder
ü     Imipramine is used to control bed-wetting in children of more than 6 years of age
ü     Amitriptyline has been used to treat migraine headache and chronic pain syndromes (e.g. naturopathic pains) and when the cause of pain is not clear.

Adverse Effects:

Adverse effects are because of unwanted effects of TCAs on alpha-adrenergic and cholinergic histaminic receptors. TCAs block these receptors.

Following are the common adverse effects of TCAs:

*    Dry mouth
*    Constipation
*    Urinary retention
*    Blurred vision
*    Tachycardia
*    Arrhythmias
*    Nausea
*    Drowsiness.
*    Weight gain

Labels:

Comments

  1. AnonymousNovember 20, 2012 at 10:59 AM

    You cаn cеrtainly ѕее youг expеrtisе іn the woгk yоu wrіtе.

    Τhe ωorld hopes for more passionаte wrіterѕ such aѕ уou whо are not аfrаіd to ѕaу hoω thеy beliеve.
    All the time follοw your heaгt.
    Feel free to visit my web site ; free money forex

    ReplyDelete

Post a Comment

Post Your Reply and Give Your Opinion About the Post

Popular posts from this blog

Human Parasites, Types of Parasites, and Classification

Parasite: A parasite is a living organism which gets nutrition and protection from another organism where it lives. Parasites enter into the human body through mouth, skin and genitalia. In this article, we will generally discuss the types and classification of parasites. It is important from an academic point of view. Those parasites are harmful, which derives their nutrition and other benefits from the host and host get nothing in return but suffers from some injury. Types of Parasites Ecto-parasite: An ectoparasite lives outside on the surface of the body of the host. Endo-parasite: An endo-parasite lives inside the body of the host, it lives in the blood, tissues, body cavities, digestive tract or other organs. Temporary parasite: A temporary parasite visits its host for a short period of time. Permanent parasite: Permanent parasite lives its whole life in the host. Facultative parasite: A facultative parasite can live both independently and dependently. It lives in the...
Post a Comment
Read more.>>

How to taper off, wean off beta blocker, atenolol, Propranolol, Metoprolol

Beta blockers include, atenolol (Tenormin), propranolol (Inderal ) and metoprolol (Lopressor) and are used to treat high blood pressure, certain cardiac problems, migraine and few other conditions. People usually take atenolol, propranolol or metoprolol for many years as a treatment of high blood pressure or after having an episode of heart attack . Sometimes, it becomes necessary to withdraw these beta blockers due to their potential side effects that trouble the patients or sometimes doctor wants to change the drug and shift the patient to some other anti-hypertensive medicine. No matter whatever the cause is, whenever, a patient who has been using a beta blocker for a long period of time, and he needs to be stopped from further usage of that beta blocker, must not stop taking it. One should taper off the dose of a beta blocker. Now a question arises how to wean off or taper off a beta blocker? The method of tapering off beta blocker varies from individual to individual. Allow you...
Post a Comment
Read more.>>