Serotonin-Nor epinephrine re-uptake inhibitors - Mechanism - Indications - Adverse/side effects

Serotonin-Nor epinephrine re-uptake inhibitors - Mechanism - Indications - Adverse/side effects - Antidepressants drugs

Serotonin-Norepinephrine Re-uptake Inhibitors – SNRI’s

SNRI’s inhibit the presynaptic reuptake of both serotonin and nor epinephrine. Those patients who don’t respond to SSRI,s may show response to SNRI,s

These drugs are similar in the action of Tricyclic antidepressants but differ in side effects profile. SNRI’s have fewer side effects and are better tolerated than TCA,s.

SNRI,s also reduces the backache and other neuropathic pains associated with depression. SSRI,s (selective serotonin reuptake inhibitors) have no effect on pain.

The following two drugs come into this category

Ø Venlafaxine

Ø Duloxetine

Indications:

ü Depression

ü Obsessive Compulsive Disorder (OCD) (Fluvoxamine)

ü Panic disorder

ü Generalize anxiety disorder

ü Post traumatic Stress disorder

ü Bulimia Nervosa (Fluoxetine)

Adverse Effects:

Venlafaxine side effects:

Nausea

Headache

Sexual dysfunction

Dizziness

Insomnia

Sedation

Constipation

Increase in blood pressure (in higher doses

Increase in heart rate (in higher doses)

Duloxetine Adverse Effects:

Nausea

Dry mouth

Constipation

Diarrhoea

Vomiting

Insomnia

Dizziness

Somnolence

Sweating

Sexual dysfunction

An increase in blood pressure and heart rate.

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