Serotonin-Nor epinephrine re-uptake inhibitors - Mechanism - Indications - Adverse/side effects

Serotonin-Nor epinephrine re-uptake inhibitors - Mechanism - Indications - Adverse/side effects - Antidepressants drugs

Serotonin-Norepinephrine Re-uptake Inhibitors – SNRI’s

SNRI’s inhibit the presynaptic reuptake of both serotonin and nor epinephrine. Those patients who don’t respond to SSRI,s may show response to SNRI,s

These drugs are similar in the action of Tricyclic antidepressants but differ in side effects profile. SNRI’s have fewer side effects and are better tolerated than TCA,s.

SNRI,s also reduces the backache and other neuropathic pains associated with depression. SSRI,s (selective serotonin reuptake inhibitors) have no effect on pain.

The following two drugs come into this category

Ø Venlafaxine

Ø Duloxetine

Indications:

ü Depression

ü Obsessive Compulsive Disorder (OCD) (Fluvoxamine)

ü Panic disorder

ü Generalize anxiety disorder

ü Post traumatic Stress disorder

ü Bulimia Nervosa (Fluoxetine)

Adverse Effects:

Venlafaxine side effects:

Nausea

Headache

Sexual dysfunction

Dizziness

Insomnia

Sedation

Constipation

Increase in blood pressure (in higher doses

Increase in heart rate (in higher doses)

Duloxetine Adverse Effects:

Nausea

Dry mouth

Constipation

Diarrhoea

Vomiting

Insomnia

Dizziness

Somnolence

Sweating

Sexual dysfunction

An increase in blood pressure and heart rate.

Comments

Cryoglobulinemia, Cryoglobulinemia Causes, Symptoms & Treatment

Cryoglobulinemia causes Hep C Myeloma, Waldenstrom’s macroglobulinemia, SLE, Rheumatoid arthritis, Sjogren’s syndrome, Symptoms, Immunoglobulins precipitate when cooled under skin, ulcers, rashes, gangrene, Raynaud’s phenomenon. Treatment. Plasma exchange, Chemotherapy, Treat the cause.

Human Parasites, Types of Parasites, and Classification

Parasite: A parasite is a living organism which gets nutrition and protection from another organism where it lives. Parasites enter into the human body through mouth, skin and genitalia. In this article, we will generally discuss the types and classification of parasites. It is important from an academic point of view. Those parasites are harmful, which derives their nutrition and other benefits from the host and host get nothing in return but suffers from some injury. Types of Parasites Ecto-parasite: An ectoparasite lives outside on the surface of the body of the host. Endo-parasite: An endo-parasite lives inside the body of the host, it lives in the blood, tissues, body cavities, digestive tract or other organs. Temporary parasite: A temporary parasite visits its host for a short period of time. Permanent parasite: Permanent parasite lives its whole life in the host. Facultative parasite: A facultative parasite can live both independently and dependently. It lives in the...

How to taper off, wean off beta blocker, atenolol, Propranolol, Metoprolol

Beta blockers include, atenolol (Tenormin), propranolol (Inderal ) and metoprolol (Lopressor) and are used to treat high blood pressure, certain cardiac problems, migraine and few other conditions. People usually take atenolol, propranolol or metoprolol for many years as a treatment of high blood pressure or after having an episode of heart attack . Sometimes, it becomes necessary to withdraw these beta blockers due to their potential side effects that trouble the patients or sometimes doctor wants to change the drug and shift the patient to some other anti-hypertensive medicine. No matter whatever the cause is, whenever, a patient who has been using a beta blocker for a long period of time, and he needs to be stopped from further usage of that beta blocker, must not stop taking it. One should taper off the dose of a beta blocker. Now a question arises how to wean off or taper off a beta blocker? The method of tapering off beta blocker varies from individual to individual. Allow you...

MedicoTips.Com

Search This Blog